Antifungal Drug Ketoconazole Powder CAS: 65277-42-1 Shijiazhuang

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Product Name Ketoconazole Powder
CAS 65277-42-1
Formula C26H28Cl2N4O4
EINECS 265-667-4
Molecular Weight: 531.44
Assay 98%min
Appearance White or off-white crystal Powder

Antifungal Drug Ketoconazole Powder CAS: 65277-42-1
Pharmacology Ketoconazole is a pyrrole antifungal, which has antibacterial effects on deep infection fungi, such as Candida, pigmentous fungi, coccidioides, tissue plasmacytoides, sporohypha, etc., and also has antibacterial activities on tinea trichoderma, etc. This product to aspergillus, sporohypha schenker, some dark sporosporaceae, mucor and other weak action. By interfering the activity of cytochrome P-450, this product can inhibit the biosynthesis of ergosterol, the main sterol in fungal cell membrane, damage fungal cell membrane and change its permeability, so that important intracellular substances leak out. Ketoconazole can inhibit the biosynthesis of triacylglycerol and phospholipid of fungi, inhibit the activities of oxidase and peroxidase, and cause the accumulation of hydrogen per'oxide in cells, resulting in cell submicrostructural degeneration and cell necrosis. The transformation of candida albicans from spore to invasive hyphae was inhibited. Toxicology Animal long-term toxicity experiments showed that ketoconazole could significantly increase alkaline phosphatase and denaturate hepatocytes.

Ketoconazole, an imidazole-type broad-spectrum antifungal agent marketed under the trade names Jindaconin and Konin, inhibits the biosynthetic surface of ergosterol on fungal cell membranes by highly selectively interfering with the activity of fungal cytochrome P-450 Deep fungal infections are effective, can inhibit the growth of fungi, also can restrain spore into mycelium, to prevent further infection in low concentration bacteriostatic, high concentrations of sterilization For candida color fungi genera coccidioides organization of bacterial cytoplasm Spore silk bacteria genera and tinea capitis MAO bacteria, etc all have antibacterial activity Clinically applicable in the treatment of tinea manuum Athlete's foot skin tinea versicolor ringworm of the thrush As an external drug, ketoconazole lotion is mainly used for the treatment and prevention of various infections caused by Malassezia, such as tinea vata seborrheic dermatitis and scalp pityriasis (dandruff), and can quickly relieve the dandruff and pruritus caused by seborrheic dermatitis and scalp pityriasis

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