Pemetrexed disodium, an antitumor drug CAS:150399-23-8 Shijiazhuang

  CD / DVD   (Item ID: 164300)

Pemetrexed disodium is the lilly developed a treatment for cancer drugs, patent protection to January 2017, pemetrexed disodium is a structure containing a core of pyrrole pyrimidine groups more targeted folate supplements, nucleotide synthase/dihydrofolate reductase dual inhibitors, by destroying the normal metabolism of intracellular folic acid dependent process, By inhibiting cell replication, tumor growth can be inhibited by simultaneously blocking three different enzyme targets that are critical for the survival of cancer cells. In February 2004, the us food and drug administration (FDA) approved and cisplatin combination treatment for a rare form of cancer, malignant pleural mesothelioma, malignant pleural mesothelioma is a rare pleural lung cancer, pemetrexed disodium can by blocking the unique mechanism of three kinds of key enzymes of cancer cell metabolism, so as to interfere with the cancer cell replication to further promote apoptosis of tumor cells. This regimen is a triple target with a synergistic inhibitory effect, which is superior to previous single-target regimens using cisplatin. At the same time, through the supplement of folic acid and vitamin can effectively control the toxic side effects, enhance the tolerance of patients.

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