Fine Chemicals Tianeptine Sodium Salt CAS: 30123-17-2 Shijiazhuang

  Computer / Laptop   (Item ID: 190991)

Tianeptin sodium is a tricyclic antidepressant, its antidepressant mechanism is different from that of traditional tricyclic antidepressants, it can increase the reuptake of 5-HT in the synaptic space, and may have the effect of improving 5-HT neuronal conduction, which has no affinity for choline. Antidepressant efficacy is similar to that of tricyclic antidepressants, but its tolerance is better than that of tricyclic antidepressants In animal experiments, it can increase the spontaneous activity of pyramidal cells in hippocampus and accelerate the recovery after its function is inhibited. It can increase the reabsorption of 5-hydroxytryptamine by neurons in cerebral cortex and hippocampus. Tianepudine sodium is absorbed rapidly and distributed completely in the digestive tract,PPB is as high as 94% The liver was metabolized completely by β-oxidation and N-demmethylation, and the clearance terminal was short, 2.5h. A very small amount of the original drug (8%) was excreted from the kidney, mainly its metabolites excreted from the urine, and the clearance of T1/2 was prolonged for 1h in patients with renal dysfunction

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