a Drug That Inhibits Gastric Acid Secretion Omeprazole CAS: 73590-58-6 Shijiazhuang

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A drug that inhibits gastric acid secretion Omeprazole CAS:73590-58-6
Name Omeprazole
CAS 73590-58-6
EINECS 201-212-8
MF C17H19N3O3S
MW 345.42
MP 156°C
Assay 99% Min.
Appearance White Crystalline Solid
a Drug That Inhibits Gastric Acid Secretion Omeprazole CAS: 73590-58-6
Omeprazole is a proton pump inhibitor used for the treatment of peptic ulcer and gastroesophageal reflux disease (GERD) and other diseases. It can specifically act on the site of the proton pump in the gastric wall cells, and is transformed into the active form of sulfamide, and then irreversely binds to the sulfol group of the proton pump through disulfide bonds. The formation of sulfoamide and proton pump (H+-K+ -ATPASE) complex, so as to inhibit the activity of the enzyme, so that the H+ in the parietal cells can not be transported to the stomach cavity, block the last step of gastric acid secretion, can make gastric acid in gastric juice greatly reduced. Therefore, this product has a strong and durable inhibitory effect on gastric acid secretion caused by various causes (e.g., basal gastric acid secretion and gastric acid secretion caused by histamine, pentagastrin and vagus nerve stimulation, including dibutyl cyclic adenylate induced gastric acid secretion which cannot be inhibited by H2 receptor blockers). This is related to the irreversibility of the inhibition of proton pump, and only after the formation of a new proton pump, the acid-secreting effect can be restored.


Omeprazole is a proton pump inhibitor that can effectively inhibit gastric acid secretion. The trade names in circulation on the market include ampirazole omilazole, maidazole loseke, methoxesulfazolvobisole, vompirazole, which belongs to the acid-suppressant drugs, and common acid-suppressant drugs also include pantoprazole, rabeprazole Nexomepazole selectively acts on gastric mucosal parietal cells to inhibit the activity of H+,K+ -ATPase on the secretory microtubules formed by the apical membrane of gastric parietal cells and the tubular vesicles in the cytoplasm, thus effectively inhibiting the secretion of gastric acid and taking effect quickly, which is suitable for the treatment of gastric ulcer and duodenal ulcer Reflux esophagitis and stomach secrete melanoma (zhuo - ai syndrome), but need to pay attention to the excessive use of omeprazole acid suppression, such as drugs, can reduce gastric acid concentration and acidity is abate, then enter the bacteria in the stomach may not be killed, in the gut, doubled intestinal infection germs, dangerous, then it is likely that they will diarrhea Affected due to lower stomach acid digestion, and affect the intestinal calcium The absorption of trace elements such as iron and vitamins leads to calcium deficiency in the body and easy fracture

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