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What is phenacetin used for?
Why is phenacetin banned?
Is phenacetin still used?
Is phenacetin an Nsaid?
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The antipyretic effect of Dao is stronger than that of Du. The efficacy of Dao was similar to that of aspirin. Dao had a slow and lasting effect with low toxicity. The results showed that: the product and its metabolite paracetamol have antipyretic effect. When naloxone is used, it can still be used as an inhibitor of acetaminophen. Therefore, the antipyretic effect of the product is not only caused by the active product paracetamol. The mild analgesic effect of phenacetin can be maintained for 3-4 hours, and the synergistic effect of phenacetin and salicylic acid can enhance the analgesic effect. It is mainly used for antipyretic and analgesic in small animals. This product is also a component of APC tablets.
Phenacetin is a synthetic white crystalline solid, slightly soluble in water and benzene, soluble in acetone, very soluble in pyrimidine. In the study, it was used as the preferred marker for in vitro detection of CYP1A2 based inhibition potential. Ingestion of phenacetin can lead to hypoxia in the blood (violosis), dizziness and respiratory depression, leading to blue skin. It is reasonably expected that it is a human carcinogen.
In vivo process: it is easy to be absorbed by oral administration, and the effect will appear 20-30 minutes after taking it. After 5-6 hours of absorption, most of phenacetin rapidly de ethyl in the liver to produce paracetamol (paracetamol), which shows antipyretic and analgesic effects. After that, it was mainly eliminated from urine in the form of binding; a small part was deacetylated to form p-aminophenethyl ether, which changed hemoglobin into methemoglobin, thus showing cyanotic toxicity of phenacetin
People who are pursuing Lidocaine hydrochloride in the market will also pursue the following local anesthetic materials:
Lidocaine /Lidocaine hydrochloride
Benzocaine / cas 94-09-7
Tetramisole CAS 5036-02-2/ tetramisole hcl CAS 5086-74-8
November 13, 2020 8:38 am
December 31, 9999
8F,China Construction Third Bureau,Wuhan,Hubei Province, China